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The origins of QuiremSpheres® are at the University Medical Center Utrecht (UMCU). Since 1999, a dedicated team at the UMCU has worked on concept development and optimization of the production of holmium-166 microspheres. After numerous animal studies between 2004 and 2009, holmium-166 microspheres were first used in patients in 2009 with the initiation of the HEPAR I trial. After successful demonstration of clinical safety and efficacy in the years thereafter, Quirem Medical BV was founded in 2013 as a UMCU spin-off to further produce and commercialize holmium-166 microspheres. In 2015, Quirem Medical BV received CE mark for the QuiremSpheres® product. Following this milestone, Terumo Corporation and Quirem Medical entered into a strategic partnership through which Terumo obtained the exclusive distribution rights for QuiremSpheres®.



In March 2017, the first clinical case with QuiremSpheres® outside a research setting was performed at the University Clinic Carl Gustav Carus in Dresden, Germany.  More information regarding this case and the feedback of the clinical team can be found in this press release.


Tokyo-based Terumo Corporation is one of the world’s leading medical device manufacturers with over $4 billion in sales and operations in more than 160 nations. Founded in 1921, the company develops, manufactures, and distributes world-class medical devices. Terumo Corporation’s shares are listed on the first section of the Tokyo Stock Exchange and are a component of the Nikkei, Japan’s leading stock index.




Quirem Medical is an emerging medical device company with a mission to develop the next generation microspheres for targeted interventional oncology solutions. It was founded in 2012 as a spin-off of the University Medical Center Utrecht. Quirem Medical is based in Deventer, the Netherlands.




QuiremSpheres® and Q-Suite™ are not available for sale in all countries. This information is provided only in respect to markets where QuiremSpheres® and Q-Suite™ are approved or cleared. QuiremSpheres® and Q-Suite™ s not FDA cleared in the US for sale.